Exam questions

1.

Drug development – pre-registration phases of clinical trials.
Post-registration drug monitoring.
Types and design of clinical trials.
Bioequivalence studies.
Clinical significance of pharmacokinetic parameters.
Clinically relevant interactions at the metabolism level: mechanism, significance and examples.
Clinically significant interactions: sources of information, a therapeutic approach in avoiding adverse interactions.
Pharmacovigilance. Importance of monitoring drug side effects.
Pharmacoeconomic analysis: types and importance of new health technologies.
Modeling in pharmacoeconomics.
Medication policy: measures to create an economically viable drug policy, risk-sharing contracts.
Evidence-based guidelines and medicine, categories and strength of evidence.
New pharmacotherapeutic approaches in the treatment of malignancies – targeted therapy.
MEDICINE CLASSIFICATION SYSTEM (application of ATC/ DDD classifications).
Adherence – significance, methods for determining and factors affecting adherence.

2.
Guidelines for prescribing drugs in hypertension.
Cardiotropic drugs as etiologic agents in clinical toxicology.
Guidelines for the treatment of heart failure.
Guidelines in the treatment of acute coronary syndrome and acute pulmonary edema.
Basic principles for the selection and application of hypolipemics.
Guidelines for antiplatelet and anticoagulant therapy.
Therapeutic approach in patients with bronchial asthma and COPD.
Guidelines in the treatment of peptic ulcer.

3.
Guidelines in the treatment of osteoporosis.
Guidelines for pain management and administration of analgesics.
Pharmacotherapy of depression in adults – the choice of initial treatment with antidepressants.
Guidelines for the treatment of schizophrenia and other psychotic disorders.
Anxiety Treatment Guidelines.
Basic principles of rational antibiotic administration.
Stewardship antibiotic management program.
Importance of pharmacokinetic and pharmacodynamic parameters in antibiotic dosing.
Psychotropic drugs as etiologic agents in clinical toxicology.

Guidelines for type 2 diabetes pharmacotherapy.
Type 1 diabetes insulin therapy: choice of therapy.

4.

Exercise clinical case reports
1. Clinical cases – influence of pharmacokinetic and pharmacodynamic parameters on rational drug administration 1,2,3 (3 cases)
2. Clinical Cases – drug Interactions and Side Effects – 1.2 (2 cases)
3. Clinical cases – clinical toxicology 1,2 (2 cases)
4. Clinical Cases – antimicrobials 1,2 (2 cases)
5. Clinical cases – pain management 1,2 (2 cases)
6. Clinical cases – heart failure, hypertension (2 cases)
7. Clinical cases – acute coronary syndrome (1), treatment of hyperlipidemia (1), oral anticoagulant therapy (1)
8. Clinical cases – DM type I pharmacotherapy (1), DM type II pharmacotherapy (1) osteoporosis pharmacotherapy (1)
9. Clinical cases – pain management 1,2 (2 cases)
10. Clinical Cases for Teaching Units – treatment of Anxiety and Depression (2 cases)
11. Clinical cases for teaching units – treatment of asthma and COPD (1 case)
12. Clinical cases – dyspepsia (1), peptic ulcer (1)