Teaching units for first colloquium
General Pharmacology – Medicine
Fundamental principles of pharmacology. Pharmacokinetics and pharmacodynamics.
Principles of legislation and prescribing of medicines.
Pharmacodynamics.
Receptors.
Relation between structure and effect of the drugs. Down and up – regulation of receptors.
Agonists and antagonists.
Drug interactions. Synergism and antagonism.
Drug dependence.
Dosage of drugs. Doses of drugs. Therapeutic index and therapeutic window.
Membrane transport processes. Absorption. Factors that affecting absorption.
Route of drug administration. Topical and systemic drug administration.
Drug distribution.
Drug metabolism.
Importance of pharmaceutical formulations. Bioavailability. Induction and inhibition. Factors affecting drug metabolism.
Elimination of drugs.
Pharmacogenomics.
The influence of gender on pharmacotherapy.
The use of drugs during pregnancy and lactation.
The influence of age (elderly and children) and disease on pharmacokinetics and pharmacodynamics.
Adverse effects. Pharmacovigilance.
Special Pharmacology, Medicine
Classification of antibacterial agents.
Antimicrobial resistance and principles of antibacterial agents dosage.
Beta lactam antibacterials. Penicillins.
Cephalosporins. Beta lactamase inhibitors. Carbapenems.Monobactams.
Polypeptides. Glycopeptides. Lipopeptides.
Aminoglycosides. Tetracyclines. Glycilcyclines.
Macrolides. Ketolides. Lincosamides. Amphenicols. Streptogramins. Oxazolidinones.
Qiunolones.Antibacterial azoles. Sulphonamides and trimethoprim.
Antifungal drugs.
Antituberculous drugs.
Antiparasitic drugs. Antimalarics.
Antiviral agents.
Anti-neoplastic drugs.
Immunosuppressant drugs.
Respiratory infections-treatment.
Urinary tract infections-teatment
Clinical pharmacology, Medicine
Clinical pharmacology – course introduction. Clinical pharmacology and personalized medicine. Drug development, preclinical trials.
Clinical trials (stages and types of clinical trials). Ethics in clinical trials.
Clinical significance of pharmacokinetic parameters.
Clinical significance of drug interactions.
Pharmacovigilance. Importance of monitoring drug side effects.
Pharmacoepidemiology.
Pharmacoepidemiology.
Special Pharmacology, Dentistry
Classification of antibacterial agents
Antimicrobial resistance and principles of dosage of antibacterial agents.
Beta lactam antibacterials. Penicillins.
Cephalosporins. Beta lactamase inhibitors. Carbapenems. Monobactams.
Polypeptides. Glycopeptides. Lipopeptides.Amynoglycosides.
Tetracyclines. Glycilcyclines. Makrolides. Ketolides. Lincosamides.
Amphenicols. Streptogramins. Oxazolidinones. Quinolones
Antibacterial azoles. Sulphonamides i trimethoprim. Antituberculous drugs.